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Philadelphia 2023
Your immune system on the edge.
I would have liked a little break but had to interrupt it for an emergency broadcast. I’ll try and keep it short (sorry, I failed again).
Three papers have appeared in quick succession that just need to be put together and I need to tell you what they mean. And it’s a real problem. To be honest I wasn’t paying that much attention until my favourite anonymous proteomics scientist sent this message in a telegram group (btw thanks Pavel Durov, you gave us a home when twitter sent us into exile). It was about IgG4. I challenge anyone to put this better and, in inimitable Ersa-style, in so few words.
When Ersa speaks, I listen. He is a literal proteomics and genomics encyclopaedia and has been an inspiration to me for 3 years.
So when Ersa says “this is bad” I had to raise an eyebrow even though I have been trying to avoid digging into the nuances of the immunological changes associated with COVID and the mRNA vaccines.
So here are the 3 papers.
I would have liked a little break but had to interrupt it for an emergency broadcast. Three papers have appeared in quick succession that just need to be put together and I need to tell you what they mean. And it’s a real problem. To be honest I wasn’t paying that much attention until my favourite anonymous proteomics scientist sent this message in a telegram group (btw thanks Pavel Durov, you gave us a home when twitter sent us into exile). It was about IgG4. I challenge anyone to put this better and, in inimitable Ersa-style, in so few words.
When Ersa speaks, I listen. He is a literal proteomics and genomics encyclopaedia and has been an inspiration to me for 3 years.
So when Ersa says “this is bad” I had to raise an eyebrow even though I have been trying to avoid digging into the nuances of the immunological changes associated with COVID and the mRNA vaccines. So here are the 3 papers. |
Paper 1: Loacker. “The PD-L1 paper”
Here is the link: https://pubmed.ncbi.nlm.nih.
And this is the money shot.
The chart clearly shows a large and significant rise in PD-L1 expression (in immune cells).
But why? PD-L1 is the protein that T-cells use to mitigate any attack against host cells (i.e. your own body). Inhibition of PD-L1 is the basis of some of the most important and effective cancer treatments developed in the last 10 years. In fact, the most well-known PD-L1 inhibitor pembrolizumab has revolutionised the management of malignant melanoma.
Essentially this kind of immunotherapy tells your T-cells to stop ignoring the tumour cells. Kill them. Kill them all. And the T-cells go to work and kill the bad cells. Great.
So, what would happen if you do the opposite? As in, not just don’t give the Keytruda™ but actually give something that has the opposite action.
Well, that’s what that graph represents.
No worries. If you don’t have melanoma or any of the other PD-L1 mediated tumour types, maybe it doesn’t matter.
But there is another feature of PD-L1 induction which relates to immune tolerance. It means that high PD-L1 levels are a feature of an immune system that has been programmed to ignore an antigen effectively suppressing the very T-cells needed to fight off a respiratory virus.
Furthermore, if you want to keep tumour cells under control you are going to need your NK cells. What you really don’t want is the continuous production of a viral-like protein (spike) causing NK cell exhaustion. Nope, you really don’t want that.
And if you are trying to keep your NK cells working (central to the suppression of tumours), you really don’t want elevated PD-L1 expression.
But now we need to bring in the next paper…
Here is the link: https://pubmed.ncbi.nlm.nih. And this is the money shot.
The chart clearly shows a large and significant rise in PD-L1 expression (in immune cells). But why? PD-L1 is the protein that T-cells use to mitigate any attack against host cells (i.e. your own body). Inhibition of PD-L1 is the basis of some of the most important and effective cancer treatments developed in the last 10 years. In fact, the most well-known PD-L1 inhibitor pembrolizumab has revolutionised the management of malignant melanoma.
Essentially this kind of immunotherapy tells your T-cells to stop ignoring the tumour cells. Kill them. Kill them all. And the T-cells go to work and kill the bad cells. Great.
So, what would happen if you do the opposite? As in, not just don’t give the Keytruda™ but actually give something that has the opposite action. Well, that’s what that graph represents. No worries. If you don’t have melanoma or any of the other PD-L1 mediated tumour types, maybe it doesn’t matter. But there is another feature of PD-L1 induction which relates to immune tolerance. It means that high PD-L1 levels are a feature of an immune system that has been programmed to ignore an antigen effectively suppressing the very T-cells needed to fight off a respiratory virus. Furthermore, if you want to keep tumour cells under control you are going to need your NK cells. What you really don’t want is the continuous production of a viral-like protein (spike) causing NK cell exhaustion. Nope, you really don’t want that.
And if you are trying to keep your NK cells working (central to the suppression of tumours), you really don’t want elevated PD-L1 expression.
But now we need to bring in the next paper… |
Paper 2: the Irrgang IgG4 paper.
This paper is hot off the press being released during Christmas week, presumably when nobody would notice. But we did.
You can read the paper directly but I don’t think I can do it more justice than this excellent blog:
Trainwreck is the word. You see, what Rintrah (and Ersa) are saying is that the fact that there is a switch of Immunoglobulin-G (which is your standard memory antibody) to the rare form of IgG4 following mRNA COVID “vaccines” means that the immune system is collapsing.
Yeah, sorry.
As a background Rintrah points to this breakdown of IgG classes which shows the classes that perform SARS-Cov-2 neutralisation [A] and the proportion of those antibody types in convalescent (COVID-recovered) plasma [B]. So you’ll see that IgG3 does most of the work. IgG4 does not contribute at all to neutralisation of the virus. IgM is what you produce in the first week and mostly what helps you get rid of the virus.
So this is what Irrgang found, which is a HUGE rise in IgG4 and basically obliteration of IgG3 (the one you want) by the time you have got past the second or third jab.
But it’s all IgG so it’s good, right?
Wrong. IgG (immunoglobulins) are not all good. Multiple myeloma is literally a cancer that produces huge amounts of immunoglobulins and wrecks your kidneys. Of course, we all knew that when we accepted the “let’s produce huge amounts of antibodies from repeated injections for your protection” line, didn’t we?
Well, did you know that the second dose of Pfizer vaccine gave you TEN TIMES the amount of IgG? I suspect not, because by using a log scale in the Pfizer papers it looked like the second jab just gave you a little boost.
It didn’t - it gave you pseudo-myeloma.
Left, linear scale showing the IgG response to the Pfizer “vaccine”. Right, log scale (matching the chart shown in the FDA VRBPAC submissio 10th Dec 2020). On a log(10) scale a doubling of the amount actually represents an increase of 10x. It gets worse. Not only is the level of antibody production off the scale but the Irrgang paper shows that by the time of the “booster” the IgG4 proportion has risen to levels we would never see in a normal infectious process or traditional vaccine.
In fact, raised IgG4 levels are indicators of some very problematic diseases and represent immune tolerance. This is the kind of process you undergo in order to get a peanut or grass allergy under control - by subjecting your immune system to repeated doses of something it thinks it should remove. Over time, your immune system gets to think it’s part of you so stops responding to it.
Is that really what they said we were trying to achieve with this therapy?
Again, rather than go over the same ground my friend Igor Chudov explains this very clearly on his substack
Igor’s NewsletterRintrah Radagast posted a very important article yesterday. It shows us a potential explanation of why excess mortality is related to COVID boosters, why the association of Covid vaccines with mortality strengthens as time goes on instead of declining, and why…a day ago · 602 likes · 528 comments · Igor ChudovThis in itself would be enough to explain the increase in infection rates that we have been banging on about since the UKHSA vaccine surveillance reports showed that 3 doses of “vaccine” was associated with a negative efficacy of over 300%.
But if you don’t believe me, Igor, or the UKHSA (who don’t believe themselves) there is more data showing this effect - most dramatically in the recent Cleveland clinic study
Jikky the mouse 
@TheJikky@SenatorRennick This is what ADE (vaccine enhanced infection risk) looks like in clinical studies that are not suppressed by Pharma and government. medrxiv.org/content/10.110…10:02 AM ∙ Dec 23, 2022
124Likes54RetweetsAnd the effect could not be any more obvious than the abject failure of Australia to hide its embarrassing COVID data after they pushed and pushed for “boosters” when there was essentially no “COVID” to worry about.
And from a recent Freedom of Information request to South Australia Health, guess what happened to the “sick leave” days when all the staff were force vaccinated and boosted? Yeah you guessed it. This.
This paper is hot off the press being released during Christmas week, presumably when nobody would notice. But we did.
You can read the paper directly but I don’t think I can do it more justice than this excellent blog:
Trainwreck is the word. You see, what Rintrah (and Ersa) are saying is that the fact that there is a switch of Immunoglobulin-G (which is your standard memory antibody) to the rare form of IgG4 following mRNA COVID “vaccines” means that the immune system is collapsing. Yeah, sorry. As a background Rintrah points to this breakdown of IgG classes which shows the classes that perform SARS-Cov-2 neutralisation [A] and the proportion of those antibody types in convalescent (COVID-recovered) plasma [B]. So you’ll see that IgG3 does most of the work. IgG4 does not contribute at all to neutralisation of the virus. IgM is what you produce in the first week and mostly what helps you get rid of the virus.
So this is what Irrgang found, which is a HUGE rise in IgG4 and basically obliteration of IgG3 (the one you want) by the time you have got past the second or third jab.
But it’s all IgG so it’s good, right? Wrong. IgG (immunoglobulins) are not all good. Multiple myeloma is literally a cancer that produces huge amounts of immunoglobulins and wrecks your kidneys. Of course, we all knew that when we accepted the “let’s produce huge amounts of antibodies from repeated injections for your protection” line, didn’t we? Well, did you know that the second dose of Pfizer vaccine gave you TEN TIMES the amount of IgG? I suspect not, because by using a log scale in the Pfizer papers it looked like the second jab just gave you a little boost. It didn’t - it gave you pseudo-myeloma.
It gets worse. Not only is the level of antibody production off the scale but the Irrgang paper shows that by the time of the “booster” the IgG4 proportion has risen to levels we would never see in a normal infectious process or traditional vaccine. In fact, raised IgG4 levels are indicators of some very problematic diseases and represent immune tolerance. This is the kind of process you undergo in order to get a peanut or grass allergy under control - by subjecting your immune system to repeated doses of something it thinks it should remove. Over time, your immune system gets to think it’s part of you so stops responding to it.
Again, rather than go over the same ground my friend Igor Chudov explains this very clearly on his substack Igor’s NewsletterRintrah Radagast posted a very important article yesterday. It shows us a potential explanation of why excess mortality is related to COVID boosters, why the association of Covid vaccines with mortality strengthens as time goes on instead of declining, and why… a day ago · 602 likes · 528 comments · Igor Chudov This in itself would be enough to explain the increase in infection rates that we have been banging on about since the UKHSA vaccine surveillance reports showed that 3 doses of “vaccine” was associated with a negative efficacy of over 300%. But if you don’t believe me, Igor, or the UKHSA (who don’t believe themselves) there is more data showing this effect - most dramatically in the recent Cleveland clinic study Jikky the mouse @TheJikky@SenatorRennick This is what ADE (vaccine enhanced infection risk) looks like in clinical studies that are not suppressed by Pharma and government. medrxiv.org/content/10.110… 10:02 AM ∙ Dec 23, 2022 124Likes54Retweets And the effect could not be any more obvious than the abject failure of Australia to hide its embarrassing COVID data after they pushed and pushed for “boosters” when there was essentially no “COVID” to worry about.
And from a recent Freedom of Information request to South Australia Health, guess what happened to the “sick leave” days when all the staff were force vaccinated and boosted? Yeah you guessed it. This.
|
Paper 3. The coup de grace. Jiang & Mei’s p53 paper - and Michel Goldman
I’m not going to talk to much about Mei’s excellent paper because I have done it before - here:
Arkmedic's blogTLDR: A paper was published in October showing how the mRNA vaccines could massively impact ovarian and breast cancer risk. Two scientists linked to the NIH and Pharma conspired to remove it from publication - putting a generation of women at risk. Some information came to me from a colleague in the last few days that has cemented everything I have come…5 months ago · 427 likes · 233 comments · Dr Ah Kahn SyedThe paper discussed in that article showed definitively that the spike protein - the very one produced in huge quantities by the mRNA therapy - suppressed p53 activity at a cellular level. p53 is the main tumour suppressor in the body - so suppressing it (p53) is a really bad idea. Don’t do it. As explained in that article it will result in a whole host of cancers, starting with lymphomas (because T/B cells turn over faster than most other cells in the body and are directly impacted by the spike RNA).
So, now we have a problem on multiple pathways leading to the same scenario.
Suppression of the body’s defence against cancer
Suppression of the body’s defence against viruses
Exhaustion of the very components of the immune system that protect against those two things.
Do you know what this reminds me of?
Kaposi’s sarcoma. It’s what happens when your immune system is so depleted it can’t suppress tumours that are unheard of in people that have a functioning immune system. It’s seen in HIV-AIDS. Tom Hanks showed us in the original Philadelphia movie. Watch the lawyers turn away.
But it’s not 1993. It’s 2023 (give or take). And what we are seeing is not (yet) Kaposi’s sarcoma but Lymphomas and Leukaemias and rare aggressive cancers. Don’t just take my word for it - ask Professor Angus Dalgleish, one of the few clinicians to speak out.
Kat A 
@SaiKate108Today some UK doctors issued a press release to stop the shots.
Professor Angus Dalgliesh expressed concern about the incidence of aggressive cancers he is seeing after the booster.
I’m sadly seeing this amongst friends who thought they knew better and didn’t heed my warnings! 4:22 PM ∙ Dec 21, 2022
4,200Likes2,676RetweetsAnd if that wasn’t enough, how about we look at the story of another esteemed Professor who fell for the propaganda - and got “boosted”. Thing was, he already had lymphoma. It was quite well controlled in fact (as some lymphomas can be with the right treatment). Then he had his booster and his cancer went crazy.
PET scans before and after the Pfizer “booster”. Left, the black blobs (other than heart, bladder and brain) represent active lymphoma which is under control with most lymph nodes less than a centimetre. Right, the lymphoma is out of control with large volume lymphadenopathy directly attributable to the “booster”. I do commend Michel Goldman for speaking out in such a way that he wrote that paper with himself as the subject. Despite this, the media still want to use his near-death experience to silence “anti-vaxxers” and at the same time push false propaganda that the COVID-19 vaccines, which have been associated with the worst mortality of any vaccine ever, have “saved millions of lives”. They haven’t. It’s a lie.
I did reach out to Michel Goldman to let him know the documented mechanism for his disease exacerbation but I didn’t get a response. I expected no response. You see, it is so difficult for the most educated of people to accept that they have been duped.
When people ask me “why don’t the doctors who were affected speak out” the response requires an understanding of their psychology:
What is worse for a doctor is the realisation that - not only did they endanger themselves, but that they were duped and then endangered others - is too much a cross to bear. It is easier to continue the fallacy to its literal end than to accept that they were duped and put others at risk with their ignorance.
Understanding this is vital to understanding the mentality of the medical establishment. It is not an excuse, merely an observation from the ground.
I was hoping to keep this short - it’s as short as I can make it. I hope you follow the links through to those that have looked at this subject including another from the brilliant El Gato Malo. We are all trying to show you what you need to know in a way that is comprehensible, entertaining, or both.
The tide will eventually turn and those that pushed these disastrous treatments will have to be held to account.
In the meantime, whatever you do, don’t make it worse. You only get one immune system. Look after it. And let’s look forward to the coming verdicts against all those employers that fired people for refusing to subject themselves to something that they had no idea about the risks of, and didn’t care.
LIKE
I’m not going to talk to much about Mei’s excellent paper because I have done it before - here: Arkmedic's blog TLDR: A paper was published in October showing how the mRNA vaccines could massively impact ovarian and breast cancer risk. Two scientists linked to the NIH and Pharma conspired to remove it from publication - putting a generation of women at risk. Some information came to me from a colleague in the last few days that has cemented everything I have come… 5 months ago · 427 likes · 233 comments · Dr Ah Kahn Syed The paper discussed in that article showed definitively that the spike protein - the very one produced in huge quantities by the mRNA therapy - suppressed p53 activity at a cellular level. p53 is the main tumour suppressor in the body - so suppressing it (p53) is a really bad idea. Don’t do it. As explained in that article it will result in a whole host of cancers, starting with lymphomas (because T/B cells turn over faster than most other cells in the body and are directly impacted by the spike RNA). So, now we have a problem on multiple pathways leading to the same scenario.
Do you know what this reminds me of? Kaposi’s sarcoma. It’s what happens when your immune system is so depleted it can’t suppress tumours that are unheard of in people that have a functioning immune system. It’s seen in HIV-AIDS. Tom Hanks showed us in the original Philadelphia movie. Watch the lawyers turn away. But it’s not 1993. It’s 2023 (give or take). And what we are seeing is not (yet) Kaposi’s sarcoma but Lymphomas and Leukaemias and rare aggressive cancers. Don’t just take my word for it - ask Professor Angus Dalgleish, one of the few clinicians to speak out. Kat A @SaiKate108Today some UK doctors issued a press release to stop the shots.
Professor Angus Dalgliesh expressed concern about the incidence of aggressive cancers he is seeing after the booster.
I’m sadly seeing this amongst friends who thought they knew better and didn’t heed my warnings! 4:22 PM ∙ Dec 21, 2022 4,200Likes2,676Retweets And if that wasn’t enough, how about we look at the story of another esteemed Professor who fell for the propaganda - and got “boosted”. Thing was, he already had lymphoma. It was quite well controlled in fact (as some lymphomas can be with the right treatment). Then he had his booster and his cancer went crazy.
I do commend Michel Goldman for speaking out in such a way that he wrote that paper with himself as the subject. Despite this, the media still want to use his near-death experience to silence “anti-vaxxers” and at the same time push false propaganda that the COVID-19 vaccines, which have been associated with the worst mortality of any vaccine ever, have “saved millions of lives”. They haven’t. It’s a lie.
I did reach out to Michel Goldman to let him know the documented mechanism for his disease exacerbation but I didn’t get a response. I expected no response. You see, it is so difficult for the most educated of people to accept that they have been duped. When people ask me “why don’t the doctors who were affected speak out” the response requires an understanding of their psychology:
I was hoping to keep this short - it’s as short as I can make it. I hope you follow the links through to those that have looked at this subject including another from the brilliant El Gato Malo. We are all trying to show you what you need to know in a way that is comprehensible, entertaining, or both. The tide will eventually turn and those that pushed these disastrous treatments will have to be held to account. In the meantime, whatever you do, don’t make it worse. You only get one immune system. Look after it. And let’s look forward to the coming verdicts against all those employers that fired people for refusing to subject themselves to something that they had no idea about the risks of, and didn’t care.
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